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Growth cones of rat neuroblastoma B35 cells are imaged by platinum replica electron microscopy (background) or fluorescence light microscopy (foreground). Electron microscopy reveals spatial organization of the actin cytoskeleton in the growth cone and shows two prominent actin filament structures: bundles of long filaments in filopodia and branching networks of shorter filaments in lamellipodia. In the fluorescence image, the growth cone is stained with phalloidin to reveal actin filaments (green/cyan) and by an antibody to an actin filament nucleator, Arp2/3 complex (red). Actin filaments nucleated by the Arp2/3 complex are used by a cell to build both lamellipodia and filopodia in growth cones. See the article by Korobova and Svitkina on p.1561 of this issue of MBC. (Image: Tatyana Svitkina, University of Pennsylvania, Philadelphia, PA)

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