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Knockdown of the giant protein nebulin in skeletal myotubes results in a striking misregulation of actin filament length and organization at both ends of the filaments. Muscle cells were stained with antibodies to nebulin (blue) and to the Z-disc region of titin (green) and with phalloidin, which labels F-actin (red). The middle cell, which was treated with nebulin-specific siRNA to “knock down” the levels of nebulin, displays an altered pattern of phalloidin staining compared with control cells (left and right). See the article by Pappas et al. on p. 1837 of this issue of MBC. (Image: Christopher Pappas, Department of Molecular and Cellular Biology, University of Arizona)

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