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Preprint Highlight: Disentangling cadherin-mediated cell-cell interactions in collective cancer cell migration

    Published Online:
    cross validationnew methods

    Significance Statement

    • The individual contributions of E- and N-cadherin junctions in collective cell migration, especially in the context of cells transitioning between epithelial and mesenchymal states during cancer progression, are controversial.

    • This study aims to clarify the respective roles of these two cell adherens junction proteins using a combination of imaging of collectively migrating cells and a computational model of spreading behavior. The data, obtained by confinement and release of cells micropatterned on a surface, are used to develop a new model that reveals the mechanical contributions of E- and N-cadherin on cell migration.

    • The study demonstrates and validates that disrupting E- and N-cadherin cellular contacts leads to a reduction in spreading efficiency of the cell collective, a result of interest to the field of metastatic cancer research.

    This preprint has been assigned the following badges: New Methods, Cross-Validation.

    Read the preprint on bioRxiv (Zisis et al., 2021):

  • Zisis T, Brückner DB, Brandstätter T, d'Alessandro J, Vollmar AM, Broedersz CP, Zahler S. (2021). Disentangling cadherin-mediated cell-cell interactions in collective cancer cell migration. bioRxiv, 442718. doi: Google Scholar

    Cite this Preprint Highlight: DOI:10.1091/mbc.P22-02-1005

    MBoC's Preprint Highlights are commentaries written by Early-Career Editors on recent preprints of interest. They do not constitute peer review or imply publication of the original preprint by MBoC. For more information, visit